Characterising this bidirectional relationship is an open research question, and the work is early-stage
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Thus, the urine drug data method is applicable to most drugs excreted in the urine in their original form, especially when the excretion of the drug or its metabolites accounts for more than 70% of the absorbed dose
Comprehensive documentation of treatment rationale, patient consent processes, and clinical monitoring should be maintained given the experimental nature of these interventions and potential regulatory scrutiny